Ashkenazi Jews, genetic data. DNA of medieval Ashkenazi Jews in Germany
The Ashkenazi Jewish population is generally genetically quite homogeneous, with minor differences depending on the modern country of residence, which conventionally divides them into Eastern European and Western European. At the same time, despite recent progress in the study of the gene pool of Ashkenazi Jews, some demographic questions still remain open, including the time, place of the population's foundation, and routes of dissemination after the decline in numbers, as well as the time, place and sources of admixture. Studying the genomes of Ashkenazi Jews who lived closer to the time of the formation of their population may shed light on these questions. In their work, the authors examined the DNA of medieval Ashkenazi Jews of the 14th century from Erfurt in Germany, where they lived from the end of the 11th century to 1454, with a short break after, to put it mildly, the sad events in Strasbourg in 1349 and the subsequent pogroms until 1351 in the countries of Medieval Europe during the plague.
#science #history #palaeogenetics #genetics #jews #dna #germany
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Become a channel sponsor and you will get access to exclusive bonuses. More details: / @history_paleogenetics ------------------------------------------------------------------------------------ Source: Genome-wide data from medieval German Jews show that the Ashkenazi founder event pre-dated the 14th century Author: Shamam Waldman, Daniel Backenroth, Éadaoin Harney, Stefan Flohr, Nadia C. Neff, Gina M. Buckley, Hila Fridman, Ali Akbari, Nadin Rohland, Swapan Mallick, Iñigo Olalde, Leo Cooper, Ariel Lomes, Joshua Lipson, Jorge Cano Nistal, Jin Yu, Nir Barzilai, Inga Peter et al. Published: November 30, 2022 DOI: https://doi.org/10.1016/j.cell.2022.1... Additional sources: Carmi, S., Hui, K., Kochav, E. et al. Sequencing an Ashkenazi reference panel supports population-targeted personal genomics and illuminates Jewish and European origins. Nat Commun 5, 4835 (2014). https://doi.org/10.1038/ncomms5835 Xue J, Lencz T, Darvasi A, Pe’er I, Carmi S (2017) The time and place of European admixture in Ashkenazi Jewish history. PLoS Genet 13(4): e1006644. https://doi.org/10.1371/journal.pgen....
Costa, M., Pereira, J., Pala, M. et al. A substantial prehistoric European ancestry amongst Ashkenazi maternal lineages. Nat Commun 4, 2543 (2013). https://doi.org/10.1038/ncomms3543
Contents:
00:00 Introduction
04:27 Results. Historical and Archaeological Context
07:07 Kinship Relationships
07:52 Ancestry Estimation and Medieval Population Structure
11:44 Quantitative Ancestry Modeling
19:23 Historical Interpretation of Ashkenazi Jewish Ancestry Models
23:17 Evidence of Population Decline
27:07 Pathogenic Variants
28:34 Discussion and Conclusions
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