E4 Estrogen: What You Need to Know
Estetrol (E4) is a natural estrogen with remarkable properties.
0:09:16 - What is E4?
0:35:05 - E4 vs Synthetic Estrogen
0:44:15 - E4 as a Contraceptive
1:15:08 - E4 and Breast Cancer
Discovered in 1965, E4 is distinguished by its structure, boasting four hydroxyl (OH) groups.
Unlike other estrogens, E4 is exclusively produced by the fetal liver and is detectable only during pregnancy, with varying levels in the fetus and mother. Notably, E4 can be synthesized from plant sources and used for contraception and hormone replacement therapy.
What sets E4 apart is its potency and safety profile. It outshines synthetic estrogens, which pose environmental and health risks due to their accumulation and endocrine-disrupting effects. E4, on the other hand, undergoes liver metabolism and is excreted without producing carcinogenic metabolites or significantly impacting liver enzymes, lipid levels, or clotting factors.
Furthermore, E4 exhibits minimal effects on breast tissue, making it a promising candidate for menopausal symptom management and even breast and prostate cancer treatment. Clinical trials have underscored its efficacy and safety in these realms.
With E4 anticipated to be approved for menopausal use by 2026, its potential to revolutionize hormone therapy is on the horizon. Viewers are invited to delve deeper into hormonal insights by joining the Hormone Reboot Training for comprehensive understanding and exploration.
If you have any questions about hormonal health and estrogen balance, join us in the Hormone Reboot Training!
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