Directed Evolution of Proteins: Principles, Methodologies, and some remarkable applications.
#proteinengineering #directedevolution
This video explains about Directed Evolution of Proteins: Principles, Methodologies, and some remarkable applications.
Directed evolution is a powerful technique that mimics natural evolution in the laboratory to enhance or alter the properties of proteins. It involves introducing mutations into the genetic material encoding a protein and selecting or screening for variants that exhibit the desired traits.
Directed evolution enables us to harness the vast diversity of protein sequences and explore functional landscapes beyond what exists in nature. This technique allows us to overcome the limitations of traditional protein engineering approaches by tapping into the power of evolution itself.
Directed evolution has its roots in the pioneering work of Frances Arnold and her colleagues in the 1990s, who were awarded the Nobel Prize in Chemistry in 2018 for their contributions to the field. Since then, directed evolution has become a widely used and influential technique in protein engineering.
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