Circular Dichroism, or CD for short, is a powerful tool that allows us to explore the chiral properties of molecules. Chirality, as we know, refers to the property of molecules that are non-superimposable on their mirror images. CD helps us understand the differences in the way chiral molecules interact with left and right circularly polarized light.
Chirality is the quality of being asymmetric in such a way that the object cannot be superimposed onto its mirror image. This property is fundamental in nature and plays a crucial role in a wide range of fields. Chiral molecules often exist as pairs of enantiomers, which are mirror-image isomers with opposite chirality. The biological and chemical significance of chirality cannot be understated, especially in the context of drug development and understanding biomolecular interactions.
Light is typically composed of waves oscillating in various directions. When we have a wave oscillating in a single plane, we call it linearly polarized light. However, circularly polarized light takes this concept a step further. It consists of two perpendicular waves oscillating in circular paths, with one wave rotating clockwise and the other counterclockwise. This is crucial for our understanding of circular dichroism, as it involves the differential absorption of these two circularly polarized components by chiral molecules.
00:00 Introduction
00:30 Basics of Chirality
00:57 Polarized Light
01:20 CD Instrumentation
01:42 CD Spectra Interpretation
02:05 Theory Behind CD
02:37 Applications in Structural Biology
02:57 Applications in Pharmaceuticals
03:17 Applications in Material Science
03:35 Limitations & Challenges
03:54 Recent Advances
04:15 Conclusion
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