Plasma Proteins : The workhorses of Blood Plasma
What are Plasma Proteins?
Plasma proteins are a diverse group of molecules found in blood plasma, the liquid component of blood that remains after removing blood cells.
• Plasma proteins are crucial components of blood plasma, contributing to various physiological functions.
• They are synthesized primarily in the liver and serve diverse roles in the body.
• At present time over 100 different plasma proteins have been described.
The plasma proteins which are present in significantly high concentrations are:
1. Albumin
2. Globulin
3. Fibrinogen
The normal value of plasma proteins are:
– Total protein : 6 to 8 gm %
– Serum albumin : 3.5 to 6 gm %
– Serum globulin : 2 to 3.5 gm %
– Fibrinogen : 200 to 400 mg %
– A/G ratio : 1.2:1 to 2.5:1
Synthesis of Plasma Proteins
The liver is the primary factory for plasma protein production. Hepatocytes, the liver cells, house the machinery for protein synthesis. Other organs like the spleen, bone marrow, and lymphoid tissues also contribute to a lesser extent. The rate of protein synthesis can be influenced by various factors, including dietary intake, hormonal levels (e.g., thyroid hormones), and inflammatory conditions.
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