Benefits of Semaglutide: Beyond Weight Loss
Об этом видео: Benefits of Semaglutide: Beyond Weight Loss
Semaglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist, was primarily developed for treating type 2 diabetes due to its ability to improve blood sugar control. However, its benefits extend far beyond weight loss, offering significant improvements in cardiovascular health, metabolic functions, and potentially reducing the risk of various diseases.In the SELECT cardiovascular outcomes trial, semaglutide led to substantial and lasting weight loss, alongside improvements in waist circumference and waist-to-height ratio, even in patients with pre-existing cardiovascular disease, overweight, or obesity without diabetes. This trial also highlighted semaglutide's potential in reducing heart attacks, strokes, and cardiovascular-related deaths in individuals with obesity.Semaglutide primarily reduces insulin resistance through weight loss, improving glycemic control in both diabetic and non-diabetic patients. Additionally, it has been associated with improvements in blood pressure, lipid profiles, and inflammatory markers.Early data suggests semaglutide might also offer protective effects against kidney and neurological diseases. These effects are still being studied.
Semaglutide is recommended for adults with a body mass index of 30 or greater, or 27 or greater with at least one weight-related comorbidity such as hypertension, type 2 diabetes, or dyslipidemia. It is administered as a subcutaneous injection, typically once a week. The dosage often starts at 0.25 mg and is gradually increased to 2.4 mg to minimize gastrointestinal side effects and enhance tolerability.Patients on semaglutide should be monitored for gastrointestinal side effects, which are the most common adverse events, including nausea and diarrhea. These side effects are usually mild to moderate and tend to decrease over time. For optimal results, semaglutide should be used in conjunction with lifestyle modifications, including a reduced-calorie diet and increased physical activity. Intensive behavioral therapy can enhance the weight loss effects and improve long-term adherence to healthy lifestyle changes.
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