Causes of Unconjugated Hyperbilirubinemia
Prehepatic
↑ hemoglobin breakdown
autoimmune hemolytic anemia
hemolytic transfusion reaction
microangiopathic hemolytic anemia
↓ hepatic uptake of bilirubin
Intrahepatic: ↓ conjugation of bilirubin
Gilbert syndrome
Crigler-Najjar syndrome
Labs:
↑ indirect bilirubin
↑ lactate dehydrogenase
↓ haptoglobin
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