Can We Cure Aging?: Unpacking the Interventions | Andrew Steele, PhD | The Proof Podcast EP
In the past century, the average human lifespan has doubled. And while extending lifespan further might seem closer to science fiction than fact, it may not be as far away as we think. In Episode #262, I’m joined by Dr Andrew Steele for a deep dive into what he describes as the largest humanitarian crisis we are currently facing: aging.
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Dr Andrew Steele is an accomplished scientist, author, and campaigner based in Berlin. After earning his PhD in physics from the University of Oxford, he shifted his focus to computational biology, recognising aging as a profound scientific challenge. His work at the Francis Crick Institute utilised machine learning to unravel DNA complexities and predict heart attacks. As the author of "Ageless: The new science of getting older without getting old," Andrew is now dedicated to science writing and presenting, sharing his insights through his YouTube channel and in renowned publications including the Wall Street Journal, Sunday Times, Telegraph, Guardian, and WIRED magazine.
In this discussion with Dr Steele, we examine the fascinating world of aging science and the possibility of extending human lifespan. We look towards the future of this field, with Dr Steele sharing his predictions for what the next 50 years of scientific developments might look like. You’ll learn about gene editing, cellular reprogramming, cellular senescence, and common drugs used in the treatment of aging, including rapamycin and metformin.
As well as scoping future advancements, we explore what the science can tell us now. We discuss things you can do now to nurture your aging process, and what you should avoid. Dr Steele also reveals how much of aging is genetic and offers his take on the ethics of “solving” this process.
If you’ve ever wondered how stress, smoking, or brushing your teeth might impact your lifespan, you’ll find this episode intriguing and empowering.
Specifically, we cover:
00:00 - Intro
01:38 - Dr. Andrew Steele on aging
10:47 - Age-related diseases and lifespan extension
19:18 - Genetic factors, lifestyle, and gene editing for longevity
27:52 - Could gene editing help solve poor cholesterol?
34:21 - Rapamycin vs metformin for longevity
39:47 - The need for expert consensus on anti-aging interventions
47:50 - Insights on Bryan Johnson's Project Blueprint
51:24 - What are senolytic drugs?
1:05:18 - Yamanaka factors: is aging reversible at a cellular level?
1:17:42 - The rationale behind reversing aging and the future of interventions
1:25:40 - Lifestyle changes that slow the clock
1:32:41 - Calorie restriction and longevity
1:44:54 - Air quality, smoking, and vaping
1:51:18 - Stress, aging, and telomeres
1:59:05 - Are there biological reasons why women tend to live longer?
2:04:14 - Unpacking the buzz around HRT for men
2:07:23 - Environmental impact of extending human lifespan
2:14:10 - Outro
Connect with Dr Andrew Steele on Twitter and Instagram. Make sure to also head to his YouTube channel, where you’ll find videos on the ethics of prolonging lifespan and whether you can become biologically younger. Discover his book, “Ageless: The new science of getting older without getting old”, at https://andrewsteele.co.uk/ageless/, and read the free chapter on ethics.
Connect:
Twitter: / statto
Instagram: / andrewjsteele
YouTube: / @drandrewsteele
Mastodon: https://mas.to/@statto
Website: https://andrewsteele.co.uk/
Book: https://ageless.link/
Free book chapter: https://ageless.link/ethics
If you have any additional questions you would like answered in the future, let me know in the comments.
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Enjoy, friends.
Simon
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