NIH Science in Seconds – a weekly roundup of NIH’s research news. Read more about each of the featured news stories below.
Week of June 19, 2023
1. Myasthenia gravis is an autoimmune disorder that causes muscle weakness. A new clinical trial suggests the advanced blood cancer immunotherapy known as CAR-T could be adapted to treat myasthenia gravis, offering a longer-lasting reduction in symptoms than current treatments. https://go.nih.gov/BOblwxi
2. Screening newborns for a deadly immune disease called severe combined immunodeficiency (SCID) can significantly boost the five-year survival rate of affected children, according to an NIH-funded study. Researchers hope more countries will introduce population-wide newborn screening for SCID. https://go.nih.gov/n9aVyVA
3. New research from an NIH-funded clinical trial found that taking low doses of aspirin daily increased the risk of anemia in people aged 65 years and older by approximately 20%. Given these findings, care providers may want to consider periodic monitoring of red blood cells or hemoglobin. Anemia in older adults is associated with dementia, cognitive decline and depressive symptoms. https://go.nih.gov/W2yg0wE
4. Xylazine is the active ingredient in a veterinary tranquilizer often added to illicit opioids. A study in rats suggests that when used in combination with opioids, xylazine may damage the ability of the brain to get oxygen. The research helps deepen understanding of how xylazine impacts overdose risk. https://go.nih.gov/8hteeSU
5. Using 3-D models of ovarian cancer tumors, scientists found differences in gene activity based on the location of the cancer cell in the tumor. This approach could eventually lead to more precise therapies by providing insight into cancer progression and treatment response. https://go.nih.gov/dN22NUT
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