#22944
Effects of locally administered human Muse cells on bladder inflammation, overactivity and nociception in a chemically induced interstitial cystitis-like rat model
Furuta A1, Kuroda Y2, Igarashi T1, Kimura T1, Suzuki Y3, Egawa S1, Dezawa M2, Yoshimura N4
1. Department of Urology, Jikei University School of Medicine, Tokyo, Japan, 2. Department of Stem Cell Biology and Histology, Tohoku University Graduate School of Medicine, Sendai, Japan, 3. Department of Urology, Tokyo Metropolitan Rehabilitation Hospital, Tokyo, Japan, 4. Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
KEYWORDS: Animal Study, Painful Bladder Syndrome/Interstitial Cystitis (IC), Basic Science, Stem Cells / Tissue Engineering
Human multilineage-differentiating stress enduring (Muse) cells, a novel nontumorigenic pluripotent-like stem cell population, reside in the bone marrow, skin and adipose tissues, and can be collected as cells positive for stage-specific embryonic antigen-3 (SSEA-3), a surface marker for human embryonic stem cells. There are approximately 1% of SSEA-3-positive Muse cells in bone marrow-derived mesenchymal stem cells (BM-MSCs) [Ref.1]. Thus, we investigated the effects of locally administered human Muse cells on bladder tissues, function and nociceptive behavior in a chemically induced interstitial cystitis (IC)-like rat model.
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