#23300
Effect of citalopram and reboxetine on urethral closure mechanism: A randomized, double-blind, placebo- and active-controlled crossover study in healthy women
Christoffersen T1, Sonne D1, Kornholt J1, Sonne J1, Klarskov N2
1. Dept. of Clinical Pharmacology, University Hospital Bispebjerg & Frederiksberg, 2. Dept. of Gynecology & Obstetrisc, University Hospital Herlev & Gentofte
KEYWORDS: Stress Urinary Incontinence, Female, Clinical Trial, Pharmacology
Over the last decades, the exact role of the serotonergic system on micturition and urinary continence in women has been investigated and discussed. Traditionally, central serotonergic pathways are considered to have a positive effect on urethral closure mechanism. However, recent clinical trials and experimental animal studies demonstrate conflicting results regarding the effect of serotonergic drugs on urethral pressure (1,2). Furthermore, observational studies suggest that exposure to selective serotonin reuptake inhibitors (SSRI) is associated with a significant increased risk of stress urinary incontinence (SUI) (3). In the light of the extensive use of SSRIs, it is relevant to investigate whether SSRI decreases urethral pressure, which potentially could worsen SUI. The aim of this study was to evaluate the effect of citalopram, a SSRI, on opening urethral pressure (OUP) in women.
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