An intro to RNA interference (RNAi), microRNA (miRNA), and Argonaute (Ago)
RNA interference (RNAi) regulates the amounts of thousands of molecular workers inside a body’s billions of cells. If it malfunctions, cancer or other diseases can develop. In addition to being a fundamental life process, RNAi’s ability to silence specific genes makes it a powerful experimental and therapeutic tool. At its center is a protein called Argonaute (Ago). Ago works by binding small RNAs (including microRNAs (miRNAs) and siRNAs) which serve as guides, enabling it to find and bind partially or fully-complementary sequences in target messenger RNAs (mRNAs). Then, alone or with the help of cofactors, Ago can prevent those mRNAs from being used as recipes to make proteins. I study how Ago does all this awesomeness and there's 1 week until my thesis defense so here's a version of the intro I wish I could give so my family and friends could get a basic overview before I dive into the details.
for more detailed text and figures see: http://bit.ly/microRNARNAi
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