Discover our digital sub-micro meter scale reconstruction of the Neuro-Glia-vascular architecture!
The EPFL Blue Brain Project created the first digital reconstruction of the Neuro-Glia-Vascular (NGV) Architecture providing a new framework to study brain function in health and disease.
The 2021 study, published in Cerebral Cortex, represents a major milestone for Blue Brain because it is now able to reconstruct the architecture of non-neuronal entities such as blood vessels and the supporting cells called glia. This means it is possible to capture the way that neurons, glia and the blood supply interact. These reconstructions of the brain tissue provide a sub-micron precise framework needed to simulate the molecular interactions relevant to understanding how neurons are supported and nurtured. They can also be used to investigate how drugs interact and explore how neurodegenerative diseases arise. Blue Brain has made all the experimental data, models and tools used to reconstruct brain tissue at this resolution open source.
Access the digital reconstruction – https://bbp.epfl.ch/ngv-portal/
See the original publication - https://academic.oup.com/cercor/artic...
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