Blue Brain Virtual Talk - Huib Mansvelder, Professor of Neurophysiology at the Vrije Universiteit Amsterdam
Abstract and bio:
https://memento.epfl.ch/event/blue-br...
00:00 Cortical neuronal diversity supporting human cognition – Introduction
00:45 Mental ability
02:40 Do humans have more neurons in brain areas for cognition?
03:37 Evolutionary expansion of human cortical layers 2 and 3
04:35 Multi-level study of human brain function of the same subject
06:49 Temporal cortex gray matter thickness associates with IQ
09:00 Temporal cortical L2 and L3 thickness association with verbal IQ
10:45 How does the expansion of L2/L3 affect the overall microstructure of these layers?
11:42 ‘Patch-seq’: Physiology, Morphology & Transcriptome of the same cell
12:46 Dendrite length associates with cortical thickness and IQ scores
14:10 Human dendrites are larger, more complex, and receive more synapses
14:48 Human excitatory synapses are stronger and more reliable
16:17 Modeling: A single human synapse transfers more information
17:36 Broadband input-output function: Human pyramidal neurons can reliably time AP output to input
20:38 Human APs remain faster during repeated firing
22:18 Higher IQ associates with faster AP rise speed
24:00 AP shape stability and Na+ and K+ currents
25:33 Human Na+ currents are more resistant to inactivation
26:26 Modeling: Inactivation properties of Na+ channels determine AP speed and stability
27:43 Intermediate conclusions 1
28:04 Evolutionary conserved fast signaling and rhythms across brain sizes
30:36 Larger distances, travel faster...
31:31 Reconstructing the time course of fast inhibition in human and mouse circuits: What are the mechanisms?
32:18 Interneuron diversity in human cortex
32:37 FS neurons morphology: longer, but fewer dendrites
33:28 Modeling excitatory inputs on FSINs with human or mouse morphologies
34:29 Excitatory inputs: similar strength, delays and kinetics in human and mouse FSINs
34:58 Modeling excitatory inputs on FSINs with human or mouse morphologies
37:02 Fast AP properties in human FSINs
38:18 FS to Pyr connections are faster in human
39:11 Intermediate conclusions 2
40:21 How do genes, neurons and circuits support human intelligence?
41:37 Linking genes to neuron types: expression in adult human neurons in areas of intelligence?
42:39 Large L3 neurons express more genes of intelligence
43:53 Expression of genes associated with IQ correlate with total dendritic length (TDL)
45:07 Expression of genes associated with IQ correlate with AP rise speed
45:54 IQ genes correlated with pyramidal neuron TDL and fast APs contain more human evolution genes (HARs)
47:30 Genes correlated with TDL and fast APs are enriched in neuronal signaling and ...
48:30 …synapse function
49:15 Brain expansion and evolution of mental ability
50:02 Linear evolution of neuronal properties may accelerate mental evolution
51:07 Thanks