Contribution of Neanderthals to the DNA of modern humans. Blood groups of Neanderthals & Denisovans
I bring to your attention a review of several articles on the contribution of the Neanderthals to the gene pool of modern people, as well as on their blood groups with the Denisovans.
Content:
00:00 Introduction
00:12 Quantification of the introgression of Neanderthals into the heritability of complex traits of Homo sapiens sapiens
09:53 Neural network and archaic admixture in modern people
10:54 Blood groups of Neanderthals and Denisovans
In a recently published work, the authors, using the well-established genome-wide search for associations (GWASs) for 405 different traits, tried to characterize the effect of Neanderthal admixture on the heritability of complex traits in Europeans and to determine trends in the direction of the influence of introgressed variants on these traits. And also to understand how the introgression of the Neanderthals could contribute to adaptation to a non-African environment.
In another scientific work, which was published in the same year, the authors reported on the search for adaptive regions of an archaic impurity in modern humans using a convolutional neural network.
In another study, the authors analyzed the blood types of Neanderthals and Denisovans to trace the origins of current human diversity and discuss aspects of the health and vulnerability of archaic populations. For this, previously published high-quality nuclear genomes from three Neanderthals and one Denisovans were used.
#genetics #dna #history #biology #anthropology
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Sources:
1. McArthur, E., Rinker, D.C. & Capra, J.A. Quantifying the contribution of Neanderthal introgression to the heritability of complex traits. Nat Commun 12, 4481 (2021). https://doi.org/10.1038/s41467-021-24...
2. Detecting adaptive introgression in human evolution using convolutional neural networks Graham Gower Is a corresponding author, Pablo Iáñez Picazo, Matteo Fumagalli, Fernando Racimo Lundbeck GeoGenetics Center, Globe Institute, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark; Department of Life Sciences, Silwood Park Campus, Imperial College London, United Kingdom
https://doi.org/10.7554/eLife.64669
3. Condemi S, Mazières S, Faux P, Costedoat C, Ruiz-Linares A, Bailly P, et al. (2021) Blood groups of Neandertals and Denisova decrypted. PLoS ONE 16 (7): e0254175. https://doi.org/10.1371/journal.pone....
Supporting materials:
Paul hudson
flickr.com/photos/pahudson/13809176994/
Allan henderson
flickr.com/photos/allanhenderson/29080690335/
Neanderthal-Museum, Mettmann - Pressebilder Neanderthal Museum, Mettmann, neanderthal.de/de/urmenschen.html, 94895245
Paul Hermans - 89535606, 89535597, 89535599, 89535598
en: User: Samir_ (The_Scope), vectorized commons.wikimedia.org/wiki/User:Fvasconcellos Translation into Russian: Gingreen - en: Image: Patterns_of_CD.svg, ru.wikipedia.org/w/index.php?curid=412969
Goeland1234 - 43706929
Michael Plotke - 24288958
Tomasz Grel (deepsense.io) - deepsense.io/region-of-interest-pooling-explained/, CC 4.0, 57732987
Muntuwandi 14930596
Muntuwandi, 14930588
anthro palomar - wiki / File: Map_of_blood_group_b.gif, Based on diagrams from anthro.palomar.edu/vary/vary_3.htm which were reproduced from From AE Mourant et.al., The Distribution of the Human Blood Groups and Other Polymorphisms, 2nd ed. (1976), 14930628
Emw - 8761486
NIAID - Norwalk Virus, 39933110
Fährtenleser - 93739568
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