Genotype-Phenotype nonlinearity of penetrance and expressivity
While technology has enabled us to identify our alleles, our genotypes are not always indicators of our phenotypes. Hence, decisions on disease treatment and abortion must consider the non-linearity between genotype and phenotype. This video discusses the non-linear genotype-phenotype relations of incomplete penetrance and variable expressivity. Only when we answer the question can we have a clearer picture of our understanding of the concepts, so there are questions to try at the end, which you can pause to answer before listening to the answer.
Timeline
00:00 Importance of understanding that there can be non-linearity between genotype and phenotype.
00:18 Penetrance, Incomplete penetrance, and Complete penetrance
01:26 Cause of incomplete penetrance
02:26 Variable expressivity
03:04 Summary
04:00 Questions and Discussion of answers
07:51 References
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