ConnectivityMap (CMap)
Over the years, several computational approaches have been developed to discover such links. These methods can be classified based on how the links are defined into (1) structural similarity-based approaches that screen for new drugs from candidates that are structurally similar to a known drug; (2) network-based methods that predict connections between drugs and diseases based on shared targets, pathways, disease phenotypes, drug indication, and/or side effects; and (3) gene expression profile-based similarity, or connectivity mapping, that searches for drugs with gene expression profiles that are negatively correlated with disease-associated gene expression profile, with the assumption that a drug with “reversed” gene expression to that of disease could potentially relieve the disease by drive gene expression toward the normal state. In this module, we will focus on connectivity mapping-based drug repurposing.
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