Catalyst Researcher AMA
Each week, you will have the opportunity to hear directly from the researchers about their innovative work and their reasons for seeking funding from the DeSci community. You'll be able to ask questions, add input, and learn about insanely cool niche science topics. 🧠
🗣️ Our first guests are two senior researchers with over 50 years of combined experience in the lab. Driven by a desire to combat the protein clumping that drives neurodegenerative disorders such as Alzheimer's Disease, they have identified two potential therapeutic candidates and are seeking support to pursue them.
We'll leave you with one final hint - the project called Project Transfidelity...
0:54 Opening
1:11 Molecule Launches Catalyst
1:50 VitaDAO Introduction
2:33 Researcher AMA Goals & Researcher Intros
6:37 What is the story behind this research?
11:00 What evidence exists for the association between translation fidelity and age-related diseases?
14:02 The two processes of aging
15:30 Age Related neurodegenerative diseases related to aggregation of specific proteins
19:28 Proejct Transfidelity research approach
21:25 What does the funding aim to cover?
28:31 Drugs that have been screened, on or off target
30:45 Molecule and VitaDAO Goal, to support scientists
31:27 Why focus on the target versus going to compound optimization?
35:55 Do the compounds interact with the proteolytic machinery, and does that matter?
39:17 What evidence do you have that shows that it's the translation error rate and translational fidelity that is casual of these aggregates that end up becoming pathogenic?
43:45 Closing
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