New drugs to beat Ebola
Two potential drugs have been discovered for treating Ebola Virus Disease (EVD). The two drugs are REGN-EB3 and mAb114. They co-function with human antibodies to neutralise Ebola virus. REGN-EB3 is a mix of three antibodies while the other one is a single-antibody drug. From the preliminary test results of first 499 patients, REGN-EB3 and mAb114 showed only 29 percent and 34 percent death rates respectively. REGN-EB3 is developed by infecting mice with the ebola virus.
mAb114 antibodies were extracted from the white blood cells of Ebola survivor of the1995 outbreak in Democratic Republic of Congo (DRC). Other two drugs, ZMapp and remdesivir, showed high death dates and were hence discarded. The trials which went underway in November 2018 was a multi-country and multi-agency project.
Director-general of Congo’s Institut National de Recherche Biomédicale Jean-Jacques Muyembe-Tamfum and deputy director of US-based NIAID, Richard T Davey, are co-principal investigators. The trial was done on Ebola patients in the DRC. The drug would be injected in form of vaccine. However, it is not preventive but helps only in treatment.
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