Former News Of The World editor Rebekah Brooks and her racehorse trainer husband Charlie are among six people arrested by police investigating phone hacking.
Five men and one woman were detained this morning on suspicion of conspiracy to pervert the course of justice, Scotland Yard said.
Brooks' former PA was arrested on a similar charge earlier this year.
The co-ordinated arrests were made by officers from Operation Weeting, the Metropolitan Police investigation into illegal hacking of voicemail messages.
Brooks and her husband were at home in Oxfordshire when they had a very early call from the police, Sky News crime correspondent Martin Brunt said.
Scotland Yard said the four other men - aged 39, 46, 38 and 48 - were arrested at properties in Hampshire, London and Hertfordshire.
A number of addresses connected to the arrests are being searched, police added.
The former newspaper editor and ex-News International chief executive was arrested and bailed last summer on suspicion of phone hacking and corruption.
Her lawyer has said she denies committing any criminal offence.
Brooks was the editor of the News Of The World (NOTW) and The Sun before becoming chief executive of News International in 2009.
A public furore erupted last July after it was revealed that a private detective working for the NOTW hacked the mobile phone of murdered schoolgirl Milly Dowler.
Brooks resigned as News International chief executive last year.
Charlie Brooks is an old friend of Prime Minister David Cameron - they were at Eton together and maintain a close friendship.
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