Two mechanisms of Pattern formation in models of the interior of living cells
on channel: Instituto de Física Interdisciplinar y Sistemas Complejos (IFISC)
By: Sergio Alonso, Physikalisch-Technische Bundesanstalt, Berlin, Germany
Date: 2013-05-31 11:30:00
Description: Multitude of biochemical reactions happen simultaneously inside living cells. Depending on the necessity of the cell, such reactions can be activated or inhibited by chemical signals and also regulated through spatial or mechanical constraints. These control processes may produce the formation of static or dynamic spatio-temporal distributions of chemical substances inside the cell, giving rise to pattern formation. I show two mechanisms of pattern formation inside cells and I discuss their application to different biologically relevant problems:
1) Phosphorylation and dephosphorylation of proteins are processes of activation and deactivation which regulate many cell reactions. When these processes are assumed to occur in a well-mixed environment inside the cell, the classical Goldbeter-Koshland model of protein phosphorylation and dephosphorylation precludes the formation of stable inhomogeneous states. The introduction of spatially localized enzymatic action at the cellular membrane produces the spontaneous formation of domains of phosphorylated proteins.
2)Biochemical substances regulate active stresses by the activation or inhibition of molecular motors in the cytoskeleton. Deformations in the cytoskeleton drive the displacement of the fluid part of the cytoplasm, which drags the biochemical substances. Both parts of the cytoplasm: viscoelastic cytoskeleton and viscous cytosol, are modeled as a poroelastic medium, which may produce different forms of mechano-chemical waves, including traveling, standing and rotating waves.
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