3D spatial-omics technology to study complex diseases / Cell, December 22, 2023 (Vol. 185, Issue 26)
Unbiased tracking of diseased cells in whole-organism disease models or from intact organs to examine their pathology resembles looking for a needle in a haystack. Bhatia et al. introduce a technology named DISCO-MS that solves this problem by using optically cleared tissues and robotics technology to obtain proteomics data from "sick" cells precisely identified early in the disease. Check out the paper at: http://www.cell.com/cell/fulltext/S00....
H.S. Bhatia, A.-D. Brunner, F. Öztürk, S. Kapoor, Z. Rong, H. Mai, M. Thielert, M. Ali, R. Al-Maskari, J.C. Paetzold, et al. (2022). Spatial proteomics in three-dimensional intact specimens. Cell 185.
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