How to Draw Haemoglobin Molecule Structure | Heme Molecule | TCML
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**Iron have two state - Fe +2 , Fe +3
Fe +2 : Six valence
Fe +3 : five valence
1st , 2nd , 3rd , 4th valence -- Fe link : Pyrrole Nitrogen by four coordinate bond.
5th valence -- Fe link : with imadazole nitrogen of proximal histidine.
6th valence --
Fe link : in oxyHb - with oxygen.
in deoxyHb - water molecule present b/w Fe and distal histidine.
in Hb structure :
four pyrole ring numberd (Roman nu. ) - I , II , III , IV
Bridges named -
alpha , beta , gamma , delta
Possible site of substitutions denote - 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8
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