Effect of Cymbopogon citratus Decoctions on Gasoline Vapour-induced Reproductive Toxicity in Female
Effect of Cymbopogon citratus Decoctions on Gasoline Vapour-induced Reproductive Toxicity in Female Rats | Chapter 4 | Modern Advances in Pharmaceutical Research Vol. 1
Aims: Recent research indicates that plant molecules, particularly those that are rich with antioxidant, anti-inflammatory and immune modulatory constituents, can modify and prevent the detrimental effects of gasoline compounds on reproductive endpoints. However, whether C. citratusdecoction can alleviate gasoline vapour (GV)-induced derangement of female reproductive hormones has not yet been documented. In this study, the capacity of C. citratusdecoction was evaluated for its ability to alleviate GV-induced reproductive toxicity in female rats.
Study Design: Seventy-two female Wistar albino rats weighing 185 ± 11.2 g were placed into six groups (n = 12 per group): The control (group 1, G1), GV alone (G2), GV plus C. citratusdecoction (500 mg/kg; G3), (1000 mg/kg; G4), (1500 mg/kg; G5), and GV plus vitamin C (200 mg/kg; G6).
Place and Duration of Study: Department of Physiology, University of Uyo, Uyo, Akwa Ibom State, Nigeria. All groups were treated for 35 days.
Methodology: Serum levels of the female reproductive hormones progesterone (P3) estradiol (E2), luteinizing hormone (LH), and follicle stimulating hormone (FSH) as well as superoxide dismutase (SOD) and malondialdehyde (MDA; an oxidative stress marker) in the animals were assessed using standard procedures.
Results: The results showed that GV significantly (p 0.05) decreased serum levels of P3, E2, LH, FSH, SOD and increased serum MDA levels compared to the levels in the control animals. However, co-administration of C. citratusat different doses to the animals in G3, G4, and G5 and vitamin C to the animals in G6 dose-dependently significantly (p 0.05) increased the levels of the GV-reduced reproductive hormones and antioxidant enzyme and decreased the GV-increased oxidative stress marker levels to levels similar to those in the control group.
Conclusion: Thus, C. citratusdecoction has an ameliorative effect on GV-induced reproductive dysfunction and oxidative stress.
Author(s) Details
Christopher E. Ekpenyong
Department of Physiology, University of Uyo, Uyo, Nigeria.
Read full article: http://bp.bookpi.org/index.php/bpi/ca...
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