What's THC Doing in There?
How the brain works has always been a particular source of wonder to me. I was fascinated in how the dynamics of literal brain chemistry can change the entire computational process.
Recently I have been wondering more and more about what exactly "being high" means. What is happening on a biomolecular level when we ingest cannabis? What changes in neurons that causes things to be perceived so differently?
This video wound up requiring the most reading I've ever done on a topic. The exact biomolecular mechanisms are nuanced and still not completely fleshed out. Especially with regards to processes beyond the dopaminergic pathways.
But this should be a pretty comprehensive overview of getting you up to speed on what's happening.
Used Sources:
The endocannabinoid system - https://doi.org/10.1042/ebc20190086
Review of the Endocannabinoid System - https://doi.org/10.1016%2Fj.bpsc.2020...
An Introduction to the Endogenous Cannabinoid System - https://doi.org/10.1016/j.biopsych.20...
Sustained Elevation of Dendritic Calcium Evokes Widespread Endocannabinoid Release and Suppression of Synapses onto Cerebellar Purkinje Cells - https://doi.org/10.1523%2FJNEUROSCI.1...
Adenylyl Cyclase - http://www.vivo.colostate.edu/hbooks/...
NEUROTRANSMITTER IDENTIFICATION AND ACTION: IONOTROPIC RECEPTORS VERSUS METABOTROPIC RECEPTORS - https://openbooks.lib.msu.edu/introne...
Endocannabinoid System and Exogenous Cannabinoids in Depression and Anxiety: A Review - https://doi.org/10.3390%2Fbrainsci130...
Endocannabinoid modulation of dopamine neurotransmission - https://doi.org/10.1016%2Fj.neurophar...
CB1 Cannabinoid Receptors and their Associated Proteins - https://doi.org/10.2174%2F09298671079...
Voltage-dependent modulation of N-type calcium channels by G-protein β γsubunits - https://doi.org/10.1038/380255a0
VTA GABA Neurons at the Interface of Stress and Reward - https://doi.org/10.3389/fncir.2019.00078
Cannabinoid CB1 Receptors Are Expressed in a Subset of Dopamine Neurons and Underlie Cannabinoid-Induced Aversion, Hypoactivity, and Anxiolytic Effects in Mice - https://doi.org/10.1523/JNEUROSCI.149...
Optogenetic brain-stimulation reward: A new procedure to re-evaluate the rewarding versus aversive effects of cannabinoids in dopamine transporter-Cre mice - https://doi.org/10.1111%2Fadb.13005
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