How to Calculate Inbreeding from Pedigrees
Inbreeding is the production of offspring from the mating or breeding of individuals or organisms that are closely related genetically. By analogy, the term is used in human reproduction, but more commonly refers to the genetic disorders and other consequences that may arise from expression of deleterious or recessive traits resulting from incestuous sexual relationships and consanguinity. Animals avoid incest only rarely.
Inbreeding results in homozygosity, which can increase the chances of offspring being affected by recessive traits. In extreme cases, this usually leads to at least temporarily decreased biological fitness of a population (called inbreeding depression), which is its ability to survive and reproduce. An individual who inherits such deleterious traits is colloquially referred to as inbred. The avoidance of expression of such deleterious recessive alleles caused by inbreeding, via inbreeding avoidance mechanisms, is the main selective reason for outcrossing. Crossbreeding between populations sometimes has positive effects on fitness-related traits, but also sometimes leads to negative effects known as outbreeding depression. However, increased homozygosity increases probability of fixing beneficial alleles and also slightly decreases probability of fixing deleterious alleles in population. Inbreeding can result in purging of deleterious alleles from a population through purifying selection.
Calculate the inbreeding coefficient (Fx) of the offspring denoted by (X) of the mating between the first cousins (P) and (Q )(happens in animals), assuming Fa=0.05, Fb=0.24.
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