Trachette L. Jackson: Mathematical Models of Tumor Angiogenesis
Fall 2014 Michael E. Moody Lecture Series
Trachette L. Jackson (University of Michigan)
Cancer is the collective name given to an entire class of diseases characterized by rapid, uncontrolled cell growth. To ensure continued growth, tumors must acquire a continuous supply of nutrients and the ability to export metabolic waste. They accomplish this by recruiting new blood vessels from the nearby existing vasculature, a process known as tumor-induced angiogenesis. Angiogenesis is a critical bifurcation point in cancer progression as it provides the necessary blood supply for the growth of solid tumors beyond a few millimeters in diameter. The angiogenic cascade is an extremely complex, yet well-ordered series of events involving biochemical and biomechanical signals that operate across several temporal and spatial scales. In this talk, classical and current mathematical models of tumor angiogenesis will be explored and recent advances will be highlighted.
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