Appendage Morphogenesis in Crustacean Model Parhyale Hawaiensis
The crustacean amphipod Parhyale hawaiensis is an attractive model for developmental genetic and molecular cell biology studies.
Using multi-view fluorescence light-sheet microscopy, the Tassos Pavlopoulos Lab at Janelia is able to image developing appendages at single-cell resolution over several days of embryogenesis.
Parhyale offers a unique capacity among animal models for microscopic live imaging and tracking of all cells of developing appendages continuously from early specification up to late differentiation stages.
Parhyale embryos are direct developers, they are amenable to all sorts of embryological and functional genetic manipulations, and they exhibit a striking morphological gradation along the anterior-posterior body axis.
Each embryo develops a variety of specialized appendages that differ in size, shape and pattern, offering exceptional material to study the cellular and molecular basis of tissue morphogenesis.
Visit the Pavlopoulos Lab page at Janelia to learn more: https://www.janelia.org/lab/pavlopoul...
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