NucleoTides vs nucleoSides
How to decide whether to say nucleoTide or nucleoSide? Here’s a guide… Remember: A nucleoSide is a nucleobase (base) with a side of sugar (ribose for RNA & deoxyribose for DNA). If you add phosphate group(s), you get a nucleoTide. When you see that T, think energy (rhyme that in your head) because those phosphate groups provide the energy needed to link these letters up to form nucleic acids!
* +1 phosphate gives you a nucleoside MONOphosphate (NMP (if the nucleoside has ribose as the sugar) or dNMP (if the sugar’s deoxyribose)) (e.g. AMP)
* +2 phosphates gives you a nucleoside Diphosphate (NDP or dNDP) (e.g. ADP)
* +3 phosphates gives you a nucleoside TRIphosphate (NTP or dNTP) (e.g. ATP - the energy money we keep talking about)
It may look confusing that the nucleoTides have nucleoSide in their name as written above, but that’s because it’s written as its parts - nucleoSide + phosphate (nucleoTide has the phosphate so if we wrote nucleoTide monophosphate, etc. that would be “redundant”
So, building nucleic acids up from their parts…
BASE
BASE + SUGAR = nucleoSIDE
BASE + SUGAR + PHOSPHATE = nucleoTIDE
NUCLEOTIDE + NUCLEOTIDE + NUCLEOTIDE . . . = NUCLEIC ACID
YouTube: • NucleoTides vs nucleoSides
more on nucleic acid structure here: http://bit.ly/nucleicacids2; • DNA structure - a biochemical look in...
more on AZT & nucleoside analogs: http://bit.ly/2Xb5LAL & http://bit.ly/womenresearchingHIV
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